Sensitivity analysis provides useful information for equation-solving, optimization, and post-optimality analysis. However, obtaining useful sensitivity information for systems with nonsmooth dynamic systems embedded is a challenging task. In this article, for any locally Lipschitz continuous mapping between finite-dimensional Euclidean spaces, Nesterov’s lexicographic derivatives are shown to be elements of the plenary hull of the (Clarke) generalized Jacobian whenever they exist. It is argued that in applications, and in several established results in nonsmooth analysis, elements of the plenary hull of the generalized Jacobian of a locally Lipschitz continuous function are no less useful than elements of the generalized Jacobian itself. Directional derivatives and lexicographic derivatives of solutions of parametric ordinary differential equation (ODE) systems are expressed as the unique solutions of corresponding ODE systems, under Carathéodory-style assumptions. Hence, the scope of numerical methods for nonsmooth equation-solving and local optimization is extended to systems with nonsmooth parametric ODEs embedded.