|Title||The application of an automated control strategy for an integrated continuous pharmaceutical pilot plant|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Lakerveld R, Benyahia B, Heider PL, Zhang H, Wolfe A, Testa C, Ogden S, Hersey DR, Mascia S, Evans J, Braatz RD, Barton PI|
|Journal||Organic Process Research & Development|
Continuous manufacturing offers potential opportunities for the improved manufacturing of pharmaceutical products. A key challenge is the development of an appropriate control strategy. The experimental application of an automated control strategy is presented for an end-to-end continuous pharmaceutical pilot plant. The process starts from an advanced intermediate compound and finishes with the tablet formation steps. The focus of the experimental results is on the design and performance of the control loops needed to produce a slurry of an active pharmaceutical ingredient and a solvent with specified material properties. The results demonstrate that automated control can successfully keep critical material attributes close to desired set points for a sustained period of operation. This work aims to contribute to the development of future continuous pharmaceutical processes by providing a realistic case study of automated control of an integrated continuous pharmaceutical pilot plant.