Software developed in the PSEL include

- DAEPACK, a software library for general numerical calculations,
- DFBSIM, a FORTRAN numerical integration scheme for large-scale systems of differential equations encountered in dynamic flux balance analysis.
- DFBAlab, a MATLAB tool for dynamic flux balance analysis with capabilities for dealing with non-unique LP solutions and infeasible LPs.
- DSL48S, a suite of subroutines for the numerical solution of large-scale sparse initial values problems in differential-algebraic equations and their related sensitivity systems,
- GDOC, a software library for global optimization of problems with ordinary differential equations (ODEs) embedded,
- libMC, a software library for calculating convex/concave relaxations of factorable functions as well as subgradients of these relaxations,
- Jacobian, an equation-oriented simulator for dynamic models.